The district heating (DH) system of Greece, mainly supported from lignite fired stations, is facing lately significant challenges. Stricter emission limits, decreased efficiency due to old age and increased costs are major challenges of the lignite sector and are expected to result in the decommissioning of several lignite-fired units in the coming years. As a result, managers of DH networks are currently investigating alternative scenarios for the substitution of thermal power that it is expected to be lost, through the integration of Renewable Energy Sources (RES) into the system. In this paper, the DH systems of Kozani and Ptolemaida are examined regarding possible introduction of RES. The first study examines district heating of Kozani and alternative future options for covering a part of city’s thermal load whereas the second study refers to a biomass CHP plant (ORC technology, 1MWe, 5MWth) to be powered from a biomass mixture (wood chips and straw).