Calcium looping (CaL) is considered as a very competitive technology for C02 capture emitted from fossil fuel power plants. The concept of CaL utilizes two Fluidized Bed reactors that are interconnected, where in the first reactor (carbonator) C02 is absorbed by CaO and the produced CaC03 is regenerated in the second oxy - fired calciner reactor where the captured C02 is released and further downstream can be stored. The advantage of CaL process in comparison with other C02 technologies is that the gross power output is higher by the coupling of this process with an additional steam cycle capable of recovering the released heat. Numerous studies have been undertaken for coal fired plants revealing the process effectiveness and its dominance over other competitive C02 capture technologies, such amines scrubbing and oxy -fuel combustion. Nevertheless, very few studies exist for the case of lignite .plants. The present study tries to fill the gap of existing knowledge between the coal and lignite fired plants, demonstrating that the energy penalty for sorbent regeneration in the lignite case is higher than the corresponding on in the coal oxy-firing calcination, due to its higher moisture content and lower calorific value. In this study, the application of CaL process to the 330 MWe lignite fired power plant of Meliti (Fiorina, Greece) is investigated. In this study, an advanced thermodynamic process tools (ASPEN Plus®, GateCycle®) are applied for the simulation of CaL process, as well as incorporating the effect of the various granular hydrodynamic characteristics, exhibited in the carbonator riser, phases on the carbonation-calcination rate. This information on bed hydrodynamics is retrieved from highly accurate CFD simulations, performed by the same authors using the Energy Minimization Multi - Scale scheme - Two Fluid Method (EMMS - TFM) approximation. Air Separation and C02 purification and compression units are as well simulated in detail. This study demonstrates the coupling of concepts such as a) lignite pre - drying, b) heat exchange between solid circulating streams and c) fine tuning of C02 recirculation capable for optimizing the CaL process in terms of C02 capture and net efficiency for the case of lignite fired plants.