Co-gasification of coal and solid wastes is a relatively new technique, while experience is concentrated exclusively in Northern Europe and Northern America. Taking into account not only the fact that the international energy policy trend is to promote the development of decentralized energy production units, but also the favorable attitude towards biomass and various solid waste types, BGL-gasification constitutes a promising option for industrial and district heating boilers. Compared to grate gasifiers, the BGL offers the benefits of much higher specific throughput, significantly lower gasification steam requirement, the production of molten slag and the possibility of partial or total recycle of tars and oils to the gasifier. The aim of this study is to investigate the techno-economic feasibility, concerning the installation and operation of a 30 MWe co-gasification power plant based on Integrated Gasification Combined Cycle (IGCC) technology, using lignite and Refuse Derived Fuel (RDF), in the region of Western Macedonia Prefecture (WMP)/Greece. The gasification block was based on the British Gas-Lurgi (BGL) gasifier, while the gas clean up block was based on cold gas purification. The competitive advantages of co-gasification systems can be defined both by the fuel feedstock and production flexibility but also by their environmentally sound operation. It also offers the benefit of commercial application of the process byproducts, gasification slag and elemental sulphur. The preliminary cost estimation indicated that the establishment of an IGCC RDF/lignite plant in the region of WMP is not profitable, due to high specific capital investment and in spite of the lower fuel supply cost. The technology of co-gasification is not mature enough and therefore high capital requirements are needed in order to set up a direct co-gasification plant. The cost of electricity estimated was not competitive, compared to the prices dominating the Greek electricity market and thus further economic evaluation is required. The project would be acceptable if modular construction of the unit was first adopted near operating power plants, based on parallel co-gasification, and gradually incorporating the rest process steps (gas purification, power generation) with the aim of eventually establishing a true direct co-gasification plant.