Sweet sorghum is one of the most promising energy crops for climates of Southern Europe. It has a high biomass yield and specially produces large quantities of sugars as well as lingocellulolic byproduct, which can be further exploited for the production of second generation biofuels. The present work examines the utilization of this byproduct with the combination of gasification and Fischer-Tropsch (F-T) synthesis for production of liquid biofuels. Two options for gasification were studied: 1) atmospheric with the use of air and 2) under pressure with the use of steam. Gas cleaning from constituents that could poison the F-T catalytic process is achieved in cold for the first case, while hot for the latter. Adjustment of the H2/CO ratio can be done by a) use of biohydrogen produced from the sugars of the plant, and b) typically by applying WGS reaction. The four alternative scenarios were modeled in AspenplusTM software. The results show that maximization of the liquid biofuel production can be achieved in the case air gasification is combined with the biochemically produced H2.